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Competing Interests: The authors of this manuscript have the following competing interests: R.B. Dewey, III, BS reports no disclosures. O’Suilleabhain, MD reports grants from AVID. Sanghera, PhD reports no disclosures. Patel, MD reports grants from Adamas.

Khemani, MD reports advisory boards with Lundbeck, honoraria from Lundbeck and Dallas School of Neuroscience and Sleep Medicine, and grants from NIH and Once Upon a Time Foundation. Lacritz, PhD reports advisory boards with Teva, honoraria from Omni hotel, John Peter Smith hospital, and Parkland hospital, and grants from NIH/NIA neurobiology of aging and the State of Texas, Texas Alzheimer's Research and Care Consortium. Chitnis, MD, PhD reports consultancies with Teva and Medtronic, advisory boards with Teva, honoraria from Teva, and grants from Teva, Medtronic, NIH, and Allergan. Whitworth, MD reports no disclosures. Dewey, Jr., MD reports consultancies with Teva, Acadia and Impax, advisory boards with Teva, Acadia, Lundbeck and Impax, honoraria from Teva, Acadia, Impax, Merz, US WorldMeds, Lundbeck, and UCB, and grants from NIH. This does not alter our adherence to PLOS ONE policies on sharing data and materials. Results The result of this quality improvement process was the development of a neuromodulation network.

1076 Rater Reliability of Fahn's Tremor Rating Scale in Patients With Multiple Sclerosis. The aim of this study was to determine the reliability of Fahn's Tremor Rating Scale. Fahn S, Tolosa E, Marin C. Components of the Fahn-Tolosa-Marin clinical tremor rating scale were assessed pre- and postoperatively. Visual analog scale scores for overall.

The key aspect of this program is rigorous patient assessment of both motor and non-motor outcomes tracked longitudinally using a REDCap database. We describe how this information is used to identify problems and to initiate Plan-Do-Study-Act cycles to address them. Preliminary outcomes data is presented for the cohort of PD and ET patients who have received surgery since the creation of the neuromodulation network. Introduction Treatment of disorders such as PD, ET, and dystonia requires an individualized, multi-faceted approach consisting of non-pharmacological therapy, medications, and surgical treatments. Currently, high frequency deep brain stimulation (DBS) is the most commonly recommended surgical approach when response to medication is inadequate [, ]. DBS consists of an implantable neurostimulation system that creates a non-destructive and reversible disruption of the abnormal activity in the basal ganglia or thalamus to improve motor symptoms [, ]. Selection of the target is based on disease specific considerations including the patient’s most disabling symptoms, as well as co-morbid cognitive and mood symptoms.

Once the system is implanted the device is programmed to deliver electrical current to the targeted area. Randomized trials of DBS in PD report a range of outcomes. A recent review tabulated the results of a number of studies of both STN and GPi DBS []. Of the 9 studies reporting on 943 patients undergoing STN DBS, the mean improvement in UPDRS III scores and PDQ-39 index scores ranged from 29–49% and 8.3–26.4% respectively. The same outcome measures for GPi DBS performed in 377 patients showed mean improvements of 29–39% and 6.3–17.5%.

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